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Dr Katarzyna Maresz’s, President of the ISHF, answer was published in the article “Why is it essential to pair vitamin D3 and K2” in the nutritionmag.com online magazine. Below we present part of the text and a link to the entire article.
There are some nutraceuticals that work in harmony, providing benefits that are greater together than alone. As few nutrients work better together – for example vitamins D3 and K2.
A 1993 study showed that vitamin D promotes the production of osteocalcin, which is responsible for building bone. Yet, when D was combined with vitamin K2, active osteocalcin levels are significantly increased. These findings were supported by numerous observational studies that showed low vitamin K and D status is correlated with poor bone quality and higher fracture risk.
This combination has also been identified as essential for healthy bones in children, heart health, cardiovascular health, immunity and reduction of oxidative stress. This has been confirmed by many studies and tests.

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The International Science & Health Foundation and vitaminK2.org was noticed and invited to discussion about vitamin K2 and its role for the prevention of bone fracture and support for cardiovascular health. An article “Vitamin D effects optimized with other key nutrients” was published in the New Hope Network website.
While no studies look at vitamin K status and vitamin D absorption, vitamin K2 is crucial for the beneficial action of vitamin D in the body. Both are fat-soluble vitamins and play a central role in calcium metabolism. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. Moreover, increasing vitamin D intake increases calcium absorption, particularly when combined with calcium supplementation, and promotes hypercalcemia—too much calcium in the blood. Vitamin K2 can help with this issue because it helps the body place calcium appropriately—out of the arteries where you don’t want it and into bones where you do.
“Based on the current research,” said Kate Maresz, Ph.D, President of International Science and Health Foundation – “There is enough evidence to recommend combined vitamin D3 and K2 supplementation for the prevention of bone fracture and as a support for cardiovascular health.”

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Dr Katarzyna Maresz’s, President of the ISHF, article “Promoting bone and cardiovascular health with vitamin K2” was published in “Natural Pharmacy Business” magazine. Below we present part of the text and a link to the entire magazine.
Known for bone support benefits, vitamin K2 is now recognised as vital for heart health too and the only known compound to impact hardening of the arteries. Vitamin K2 as MK-7 is the superior vitamin K, safely and effectively delivering benefits for children and adults, serving as an essential companion for calcium supplementation. By implementing this simple nutritional strategy, the population can simultaneously support their bone health, while protecting themselves from cardiovascular risk.